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KMID : 1094720200250020206
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Biotechnology and Bioprocess Engineering
2020 Volume.25 No. 2 p.206 ~ p.214
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Tunicate Cellulose Nanocrystals as Stabilizers for PLGA-based Polymeric Nanoparticles
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Jun Sang-Yoon
Park Jong-Ho
Song Hyeon-Gi
Shin Hwa-Sung
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Abstract
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Nanoparticles have different physical and chemical properties than those of micro-sized particles and are actively studied in the fields of electronics, biology, and material science. However, in case of most polymeric nanoparticles, maintaining and remaining in their colloid state for a long time is difficult due to self-aggregation. In this study, we examined the morphological, physical, and chemical properties of tunicate cellulose nanocrystals (tCNC) and also investigated the effect of tCNC on colloidal behaviors of poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles. Fourier-transform infrared spectroscopy (FTIR) showed that tCNC do not have a chemical effect on PLGA-based nanoparticles. Dynamic light scattering (DLS) showed that tCNC helped the PLGA nanoparticles maintain their small sizes for a longer period in solution. tCNC were also confirmed to be non-cytotoxic to human dermal fibroblasts at concentrations below 0.5%. Based on these results, tCNC were found to be a stabilizer for PLGA-based nanoparticles.
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KEYWORD
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tunicate cellulose, cellulose nanocrystal, poly(lactic-co-glycolic acid), stabilizer, nanoparticle
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